This study’s observations cannot be further corroborated without accounting for other factors heavily intertwined with the sex, such as the familial history of T1D, the presence of high-risk SNPs (e.g., INS and PTPN22), and especially the viral background which we postulate to be the main environmental risk factor interacting with the CXADR. Here, PTPN22 is linked to type 1 diabetes mellitus.