CDKN2A and melanoma: Moderate-to high-penetrance genes (CDKN2A, CDK4, BAP1, TERT, POT1, ACD, MITF, MC1R, and TERF2I) have been shown to effect predisposition to melanoma and account for approximately 50% of familial cases (Goldstein et al., 2008; Puntervoll et al., 2013; Aoude et al., 2014; Robles-espinoza et al., 2014; Harland et al., 2016).