The other missenses mutations in TYRP1 (c.C785T, p.T262M) and WRN (c.G1149T: p.L383F, and c.G2983A: p.A995T) were present in a heterozygous state in the patient and his brother with a brain tumor (6), while it was absent in the unaffected brother (5). The gene discussed is WRN; the disease is brain neoplasm.