Most of these are found in genes involved in multiple pathways that are known to play critical roles in melanoma development, such as pigmentation (TYR, TYRP1, ASIP, and HERC2/OCA2), nevi density (PLA2G6, MTAP/CDKN2A, CASP8, AGR3, and FTO), DNA repair (XRCC3, XPD, ATM, and PARP1), and metabolism and detoxification (GSTM1 and GSTT1) (Fargnoli et al., 2006; Goldstein et al., 2017; Artomov et al., 2018). Here, CDKN2A is linked to melanoma.