Interestingly, missense mutation in the N-terminal motor domain and the central stalk domain of KIF5A is known to be related to autosomal diseases including hereditary spastic paraplegia (Reid et al., 2002; Goizet et al., 2009; Morais et al., 2017) and Charcot–Marie–Tooth type 2 (CMT2) (Liu et al., 2014). Here, KIF5A is linked to Charcot-Marie-Tooth disease type 2.