A mutation in KIF5A could result in the accumulation of neurofilaments and hinder the transport of mitochondria, potentially serving as a hallmark of neurodegenerative diseases (Al-Chalabi et al., 1999; Palomo and Manfredi, 2015; Guo et al., 2017; Smith et al., 2017). Here, KIF5A is linked to neurodegenerative disease.