APOE and Alzheimer disease: In an early study we reported, the risk of dementia, both Alzheimer’s dementia (AD) and Vascular dementia (VaD), in those with an APOE Ɛ4 haplotype was 3–4 times higher (OR: 3.72 in AD and 2.72 in VaD) (Bharath et al., 2010).