CLIC1 and hepatocellular carcinoma: Peng et al. found that chloride intracellular channel 1 (CLIC1) recruited PIP5Ks to the leading edge of plasma membrane, accompanied with the activation of talin and integrin α4β1 and α6β4 to initiate the assembly of nascent cell-matrix adhesions and adhesion-mediated signaling for actin cytoskeleton remodeling to form lamellipodia and invadopodia, and eventually lead to extravasation and metastasis of circulating HCC cells (Peng et al., 2021).