EIF4A1 and Familial prostate cancer: Wang et al. found that for prostate cancer cells, elevated mRNA levels of eIF4A1 correlated with DNA hypomethylation levels on CpG-rich eIF4A1 islands, eIF4A1 translation products were epigenetically regulated through DNA methylation, and eIF4A1 exerted its oncogenic effects through BRD2 signaling (WANG et al., 2022).