In prostate cancer, RBBP7 interacts directly with HMGB1, which allows HMGB1 to participate in the RNA metabolic process and thus promotes cancer cell proliferation and differentiation, making the prognosis of patients with high HMGB1 expression worse (Barreiro-Alonso et al., 2021). This evidence concerns the gene HMGB1 and Familial prostate cancer.