The binding of malignancy factor Sal-like 4 (SALL4) to RBBP4 is similar in that the large and shallow acidic interaction surface of RBBP4 binds to 5 basic residues of SALL4, resulting in the interaction of SALL4 with NuRD and subsequent repression of tumor suppressor transcripts (Liu et al., 2018). Here, RBBP4 is linked to neoplasm.