Noncanonical PRC1 complex member BCOR is ubiquitously expressed across adult tissues, and mutations within this gene occur in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML), and aplastic anemia (Kelly et al., 2019). The gene discussed is BCOR; the disease is acute myeloid leukemia.