More recently, it was found that DNMT3A-mutant AML samples overexpress miR-196 family members, and morpholino knockdown of miR-196b in AML cells isolated from moribund FLT3ITD Dnmt3a heterozygous knockout mice induced significant cell death compared to negative control (Gamlen et al., 2022). The gene discussed is DNMT3A; the disease is acute myeloid leukemia.