JAK3 and acute myeloid leukemia: In addition, a high lipid diet accelerates the development of AML in a murine knock-in model for MLL-AF9 through the activation of the FLT3 receptor (Fms Related Receptor Tyrosine Kinase 3) on the membrane of c-KIT + primitive hematopoietic stem cells, with subsequent activation of the JAK3-STAT3 (Janus kinase/signal transducer and activator of transcription) signaling pathway (Hermetet et al., 2020).