RUNX1 and acute myeloid leukemia: Additionally, it has been found that patients with abnormal karyotypes, particularly those who have recurrent AML genetic changes like the t(8; 21)(q22; q22.1);RUNX1-RUNX1T1 translocation or inv(16)(p13.1q22) inversion, have higher levels of ceramide/sphingolipid production (Stefanko et al., 2017).