RUNX1 and essential hypertension, genetic: Other studies from our lab showed that Runx1 inhibition via small molecule inhibitor (Ro5-3335) blocks EHT in vivo and prevents both migration of EPCs from BM and the development of Su/Hx-PH- and monocrotaline-induced PH (MCT-PH) in mice (Figure 10) (55, 56).