In addition to RUNX1, numerous other targets of SOX17 including HGF/c-Met, E2F1, BMPR2, and estrogen metabolism have been shown to play significant roles in modulating pulmonary hypertensive responses, and perturbations in their expression may play important roles in PAH associated with impaired SOX17 expression. The gene discussed is HGF; the disease is pulmonary arterial hypertension.