Furthermore, if insufficient suppression of RUNX1 by impaired SOX17 expression causes pulmonary hypertension, it is not clear whether impaired SOX17 and RUNX1 signaling fails to maintain pulmonary vascular endothelial cell homeostasis or drives differentiation of BM-derived progenitor cells toward a myeloid fate. Here, RUNX1 is linked to pulmonary hypertension.