Sox17 enhancer knockout mice (Sox17eKO) generated by CRISPR-mediated knockdown of the SOX17 enhancer regions initially detected in PAH patients (rs10958403 and rs765727) reduces Sox17 expression in mouse lung tissue and increases human pulmonary artery endothelial cell (PAEC) permeability while decreasing endothelial cell adhesion and VEGF-induced proliferative capacity (42). The gene discussed is VEGFA; the disease is pulmonary arterial hypertension.