HMGB1 and myocardial ischemia: HMGB1 overexpression promotes hypoxia-induced apoptosis in myocardial cells, and administration of HMGB1 blocking antibody before myocardial ischemia in mice reduced apoptosis; further studies show that electin-like domain inhibits HMGB1 expression in vitro and in vivo, thereby reducing myocardial reperfusion injury and apoptosis [34].