PTGS2 and Schnyder corneal dystrophy: Cyclooxygenase 2 (COX-2) inhibitors such as R-flurbiprofen and MRS2578 are being studied in SCD (133), and lipoxygenase (LOX) inhibitors are being studied in chronic pain (134), in hopes of achieving analgesic efficacy without the undesired gastrointestinal and renal adverse effects.