IGF1 and concussion: These exosomes, enriched with IGF-1R mRNA, may enhance the sensitivity of brain cells to locally produced IGF-1, thereby promoting neuroprotection, cellular proliferation, and, ultimately, cognitive recovery.29 Therefore, the evaluation of IGF-1-related exosomes holds promise for not only advancing our comprehension of mTBI, but also revolutionizing clinical care for persons affected by this prevalent form of TBI.