Wang and colleagues reinforce the significance of IGF-1 by demonstrating its ability to improve cognitive function and anxiety behavior in rats by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/cAMP-responsive element-binding protein (CREB) pathway, which also mitigates inflammation and oxidative stress in the hippocampus.6 This evidence concerns the gene AKT1 and Anxiety.