These exosomes, enriched with IGF-1R mRNA, may enhance the sensitivity of brain cells to locally produced IGF-1, thereby promoting neuroprotection, cellular proliferation, and, ultimately, cognitive recovery.29 Therefore, the evaluation of IGF-1-related exosomes holds promise for not only advancing our comprehension of mTBI, but also revolutionizing clinical care for persons affected by this prevalent form of TBI. Here, IGF1R is linked to concussion.