PIK3CA and breast cancer: In addition, curcumin analogue, namely 1,5-bis(4-hydroxy-3-((4-methylpiperazin-1-yl)methyl)phenyl)penta-1,4-dien-3-one induced apoptosis and cell cycle arrest in MCF-7 and MDA-MB 231 human breast cancer cells by targeting the PI3K/Akt signaling (Badr et al., 2018).