It had been reported that SHC1 (SHC-adaptor protein 1) expression was closely associated with TMB, MMRs, MSI, TAMs, DNA methylation, m6A RNA methylation, tumor-associated immune infiltration and immune checkpoints in various cancers, and has been implicated in Carcinogenesis in cancer initiation, development and progression (Chen et al.2022). This evidence concerns the gene SHC1 and neoplasm.