SHC1 and cancer: It had been reported that SHC1 (SHC-adaptor protein 1) expression was closely associated with TMB, MMRs, MSI, TAMs, DNA methylation, m6A RNA methylation, tumor-associated immune infiltration and immune checkpoints in various cancers, and has been implicated in Carcinogenesis in cancer initiation, development and progression (Chen et al.2022).