Overproduction of NO by iNOS has been implicated in inflammation, rheumatoid arthritis, infection susceptibilities, inflammatory bowel disease, immune-type diabetes, stroke, sepsis, thrombosis, cancer (Bian and Murad 2003; Thippeswamy et al.2006) and multiple sclerosis (Duncan and Heales 2005). This evidence concerns the gene NOS2 and cancer.