NOS3 and arthritic joint disease: Therefore, it is generally recognized nowadays that human eNOS protein cannot be inhibited while the similarly important homologous protein iNOS is targeted by drugs for endotoxemia, inflammatory, neuropathic pain, and arthritis treatment, etc. (Cinelli et al.2020a; Garcin et al.2008), or nNOS is targeted by drugs for neurodegenerative disorders (Cinelli et al.2020b), etc.