SLC35A2 and Crigler-Najjar syndrome: It is a relatively benign condition that responds to phenobarbitone.<h4>Abstract</h4>Crigler-Najjar syndrome (CNS) type 2 is an inborn cause of isolated indirect hyperbilirubinemia characterized by a partial deficiency of the enzyme uridine 5'-diphosphate-glucuronosyltransferase (UGT) responsible for bilirubin conjugation.