AKT1 and breast carcinoma: Mahiro Iizuka-Ohashi et al. found that fluvastatin and simvastatin can promote apoptosis of breast cancer cells and inhibit cell proliferation, thereby inhibiting breast cancer growth, but this inhibition depends on the inhibition of the downstream isoprene-gerani-geraniyl pyrophosphate (GGPP), which in turn inhibits the activation of AKT [37].