Results of double immunofluorescent staining of iNOS with the marker CD31 for adrenal vascular endothelial cells or the AGRM marker CD68 in LPS-induced sepsis demonstrate that iNOS expression is upregulated in adrenal vascular endothelial cells and CD68+AGRMs rather than adrenocortical cells [141]. This evidence concerns the gene NOS2 and Sepsis.