In addition, during the progression of CLP-induced ALI or ARDS, the infiltration of neutrophils into the lung tissue causes the release of neutrophil extracellular traps and IL-1β, which upregulate the level of NLRP3, NLRP3 inflammasome assembly, and caspase-1 activation in AMs, leading to the AMs pyroptosis and sustain lung injury [95]. The gene discussed is CASP1; the disease is acute respiratory distress syndrome.