IL6 and Sepsis: In the early stage of the abdominal polymicrobial sepsis model, the survival rate of the Spred2−/− mice is improved, accompanied by increased peritoneal infiltration of leukocytes (neutrophils and macrophages) and local proinflammatory cytokines/chemokine production (IL-6, CXCL1, and CCL2), and reduced plasma and peritoneal bacterial loads.