For instance, in the mouse model, researchers have observed an initial reduction of bacteria in the blood and life-threatening sepsis hours later, representing a population bottleneck driven by efficient clearance of pneumococci by CD169+SRMs, but occasionally accompanied by intracellular replication of bacteria engulfed by CD169+SRMs, where the proliferation of these sequestered bacteria provides a reservoir for dissemination of pneumococci into the bloodstream [161,165,167]. Here, SIGLEC1 is linked to Sepsis.