In the early stage of sepsis, Ly6C−KRMs are damaged and can exacerbate SA-AKI in mice; also, intraperitoneal injection of synthetic CRP peptide 1 h after CLP can effectively prevent or control SA-AKI by increasing the number of Ly6C−KRMs, enhancing and maintaining Ly6C−KRMs ROS production, and changing Ly6C−KRMs toward M2-like subtype [33]. The gene discussed is CRP; the disease is acute kidney injury.