BC survivors experienced significant reductions in most of the metabolic and hormonal biomarkers immediately after the 3 months of lifestyle intervention (i.e., glycemia, insulin, triglycerides, LDL, total cholesterol, and testosterone), significant decreases in glycemia and insulin were also observed up to 12-month follow-up time points (T1, T2, and T3), by contrast at 24-month (T4) values were only slightly reduced vs. T0. This evidence concerns the gene INS and breast cancer.