Our previous study found that Shengmai Yin (SMY) can reduce the occurrence and development of DCM by regulating the NLRP3/caspase-1 signaling pathway [16], however, it is not clear whether SMI alleviates high-fat-induced myocardial cell injury by regulating NLRP3 signaling pathway. The gene discussed is NLRP3; the disease is familial dilated cardiomyopathy.