AIFM1 and hearing loss disorder: In three subjects (cases 46, 51, 68), simple hearing loss was identified to be caused by mutations in AIFM1. In case 46, the average hearing threshold improved from 78.25 dB to 40 dB, the CAP score increased from 0 to 3, and the SIR score improved from 1 to 5 after three years of operation.