Wang et al. (2017) examined TILS-induced metabolic and hemodynamic coupling in order to quantify the coupling strength between TILS-enhanced cerebral metabolism and hemodynamic response. They found that young, healthy adults had a strong neurovascular coupling between the change of [CCO] and [HbD] during and post-TILS, with a coefficient of determination of R2 = 0.96. We conducted the same analysis in our older adults with BD and found a much weaker coupling between change of [CCO] and [HbD], during and post-TILS, with R2 = 0.34. This evidence concerns the gene HBD and Behcet disease.