GBA1 and Parkinson disease: The most common genetic risk factor for PD are mutations in the GBA gene (Kovanda et al., 2022), and is the gene with the clearest evidence thus far, indicating that both STN and GPi DBS can have a solid impact on motor symptoms, albeit with an increased risk of cognitive decline than in noncarriers (Weiss et al., 2012; Lythe et al., 2017).