STXBP1 and epilepsy: In recent years, genetic variants in epilepsy have been identified, such as STXBP1, SYNGAP1, tuberous sclerosis complex 1 and 2 (TSC), SCN1A, KCNQ2, CDKL5, GNAO1, PCDH19, SHANK3 and Dup 15, which cause genetic epilepsy with onset in the first three years of life (4).