Two studies reported outcomes of IL-27 in the detection of sepsis, the pooled sensitivity was 0.80 (95% CI: 0.72, 0.87; I2 = 94.0%, p = 0.001) and the pooled specificity was 0.74 (95% CI: 0.65, 0.82; I2 = 28.0%, p = 0.239), respectively. Here, IL27 is linked to Sepsis.