Two studies reported outcomes of IL-10 in the detection of sepsis, the pooled sensitivity was 0.89 (95% CI: 0.79, 0.95; I2 = 65.3%, p = 0.090) and the pooled specificity was 0.83 (95% CI: 0.75, 0.89; I2 = 0%, p = 0.523), respectively. This evidence concerns the gene IL10 and Sepsis.