Hallows et al. (100) found a positive association between urinary excretion of PKM2 and LDHA and ADPKD severity (assessed by htTKV and eGFR) in 95 ADPKD patients (161), thus providing evidence of up-regulated glycolytic flux as a feature of ADPKD severity. Here, LDHA is linked to autosomal dominant polycystic kidney disease.