Salih et al. (68) reported five- to six-fold higher levels of urinary AGT and renin excretions in ADPKD patients (n = 60) compared to sex, eGFR, blood pressure and RAAS inhibitor use matched non-ADPKD CKD patients (n = 57), while plasma levels of AGT and renin did not differ between the groups. Here, REN is linked to autosomal dominant polycystic kidney disease.