Segarra-Medrano et al. reported elevated urinary levels of markers of tubular injury (KIM-1 and β2MG) and renal ischemia (VEGF and MCP-1) and their significant correlation with htTKV and eGFR in 130 ADPKD patients (87). This evidence concerns the gene HAVCR1 and autosomal dominant polycystic kidney disease.