Among various molecules under investigation, the most promising ones for predicting ADPKD progression are copeptin, apelin, angiotensinogen, FGF23, suPAR, serum bicarbonate, sFRP4, KIM1, MCP1, β2MG, CD14, fetuin A, osteopontin, along with asymptomatic pyuria, urine osmolality and urine to plasma urea ratio. The gene discussed is SPP1; the disease is autosomal dominant polycystic kidney disease.