Most importantly, in a cohort of early-stage ADPKD patients, urinary Fetuin-A concentrations significantly increased during 2 years of follow-up without a concomitant increase in eGFR, suggesting that the urinary level of Fetuin-A might be a more sensitive biomarker for detecting disease progression than eGFR. Here, AHSG is linked to autosomal dominant polycystic kidney disease.