We observed that high levels of H2O2-mediated oxidative stress (200 and 400 μM) reduced the activity of the Akt/bcl-2 pathway and increased the expression of p-P38 and p-JNK in colon cancer cells, but there is no influence on these signals at the low level of H2O2 (100 μM) (Figure 4). Here, BCL2 is linked to malignant colon neoplasm.