MC2R and familial glucocorticoid deficiency: While the homozygous or multiple heterozygous variants in melanocortin-2 (MC2R) have been associated with familial glucocorticoid deficiency due to unresponsiveness to adrenocorticotropic hormone (ACTH), (https://omim.org/entry/202200), we found that the c.833T>G variant was associated with the younger age of patients, suggesting more severe phenotype and earlier diagnosis.