Several other well-known variants in the genes transmembrane 6 superfamily member 2 (TM6SF2) (variant: E167K), glucokinase regulator (GCKR), membrane bound O-acyltransferase domain containing 7 gene–transmembrane channel-like 4 (MBOAT7-TMC4) (variant: rs641738), and hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) (variant: rs72613567:TA), in addition to gut microbiota composition, contribute to NAFLD susceptibility in children (13). This evidence concerns the gene TMC4 and metabolic dysfunction-associated steatotic liver disease.