In comparison with free drug and drug-loaded lipidic nanoformulation, the hybrid nanoparticles under discussion exhibited superiority in ameliorating DN evidenced by the significant reduction of urea, creatinine, TNF-α, granulocyte-macrophage colony-stimulating factor, VEGF and ICAM-1 levels with increase in LKB1 and AMPK levels. The gene discussed is TNF; the disease is liver dysplastic nodule.