The results of the IVW analysis and weighted median analysis suggest that NPC1L1 inhibitor may also increase the risk of POF (IVW: OR [95%CI] = 372.0088 [368.3797, 375.6379], p=0.14× 10−2; Weighted median: OR [95%CI] = 254.9877 [250.8620, 259.1134], p=0.85× 10−2). Here, NPC1L1 is linked to premature menopause.