VEGFA and neoplasm: It can also prolong DNA repair and promote apoptosis through inhibition of survivin, activation of transforming growth factor-β (TGF-β), PI3K/AKT/mTOR, Wnt/-catenin, NOTCH, sonic hedgehog signaling pathway (SHH), Janus kinas Additionally, quercetin can inhibit tumorigenesis by controlling VEGF and its receptors, which are the factors that stimulate tumor vascularization (55).