IRS1 and type 2 diabetes mellitus: Meanwhile, GSEA was conducted to explore the relationship between molecular function and gene expression in the GSE26168 dataset and genes related to T2D (IRS1, INSR, INS, CACNA1C, SLC2A4, CACNA1B, ADIPOQ, GCK, PIK3CD, PIK3CB, SOCS3, MAPK8, and CACNA1D) were screened (Figures 6A, B).