These investigations encompass a range of topics, including the role of pancreatic lncRNAs like Paupar in regulating glucagon secretion by α-cell genes in mice (29), the participation of lncRNAs in shaping transcriptional networks and chromatin structure within human pancreatic β cells (30), and the significance of lncRNAs such as HASTER, which acts as an antisense regulator of HNF1A, in maintaining HNF1A concentrations in pancreatic β cells during the development of diabetes mellitus (31). This evidence concerns the gene GCG and diabetes mellitus.