We identified two islet-lncRNAs (SCYL1-1:22 and POLG2-1:1) that were significantly upregulated in the islets with T2D across all tested donors, while none of the other islet-lncRNAs were found to be consistently deregulated in the islets with different BMIs (<23, >35) and T2D across the donors (Figure 8B). The gene discussed is POLG2; the disease is type 2 diabetes mellitus.