With the normalization of viruses to their cellular location and the quantification of CD45+ lymphocytes and insulin+ β cells in the pancreas we confirmed and verified the increase in lymphocytes and the reduction in β-cell area in T2D in this well characterized nPOD cohort (Figure 1H), in line with previous elegant studies (6, 7, 55–57). Here, INS is linked to type 2 diabetes mellitus.