The results from both indicated that the expression levels of APOH and EGF in the fibrosis group were significantly lower than those in the control group, while the expression levels of LTF, LYZ, PLTP, and SLPI were higher (all P < 0.05), which was consistent with the six sets of DEGs in CKD samples of six microarray datasets and the renal fibrosis samples in the GSE38117 dataset of UUO mice model (Supplementary Figure 2). The gene discussed is EGF; the disease is renal fibrosis.