Meanwhile, the proportions of patients with serum ALB<LLN, PLT<LLN, ACA and/or anti-CENP-B-positive, cirrhosis, and hypertension in the PBC plus T2DM group were significantly higher than those in the non-T2DM group (all P<0.05). The gene discussed is CENPB; the disease is type 2 diabetes mellitus.