Of the other auto-antibodies that were common in PBC, the positive rates ranged from high to low, followed by anti-Ro52 (39.8%), anti-gp210 (36.4%), ACA and/or anti-CENP-B (23.7%), anti-sp100 (14.3%), anti-SSA (13.4%), and anti-SSB (3.4%). The gene discussed is TRIM21; the disease is primary biliary cholangitis.