However, the proportions of patients with serum ALB<LLN, PLT< LLN, serum IgG>ULN, serum IgA>ULN, anti-Ro52-positive especially the proportions of patients with cirrhosis in the PBC plus hyperlipidemia group were significantly lower than those in the non-hyperlipidemia group (all P<0.05). Here, TRIM21 is linked to primary biliary cholangitis.