Furthermore, AdipoQ is well-documented to have antidiabetic, anti-obesogenic, anti-atherogenic, and anti-inflammatory effects (27), which forms the basis of the protective role of AdipoQ for a wide spectrum of diseases/pathological conditions, e.g., insulin resistance in type 2 diabetes (18), metabolic disorders associated with obesity (28), atherosclerosis and cardiovascular diseases (29), and kidney malfunction with albuminuria (30). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.