ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Given that the comparative aspects of AdipoQ in the satiation response after a meal are still lacking, it will be of interest to extend our study to mammalian models (e.g., in rodents) to see if AdipoQ can also serve as a satiety factor in higher vertebrates, which for sure will have biomedical implications in appetite control and human obesity.