The IHC determination of E-cadherin is a cheaper, easily evaluable, robust, and daily-used technique in all pathology clinical laboratories, which can facilitate its implementation for somatotropinomas theragnostic assessment; and, interestingly, with no inferior (or even superior) properties to predict SRL response compared with SSTR2 (30). This evidence concerns the gene CDH1 and growth hormone-producing pituitary gland neoplasm.