In a randomized, placebo-controlled, double-masked 24-month trial on POAG patients (n = 19), Yoshida et al. [98] found that, after BCAC intake (2 capsules, 50 mg/day), the serum endothelin-1 (ET-1) concentration in POAG patients was significantly increased to levels similar to those of healthy subjects (n = 20). Here, EDN1 is linked to open-angle glaucoma.