Moreover, it has also been shown that combined treatment with Rg 3 and sorafenib significantly reduced cell viability, glucose consumption, lactate levels, and protein expression of HK2, PI3K, and Akt in HCC cells, alleviating hepatocellular carcinoma progression by regulating HK2-mediated glycolysis and PI3K/Akt signaling [52]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.