The effect of different concentrations of PT complex on the protein expression of EMT markers in human HT- 29 and SW620 cells showed a concentration-dependent downregulation of EMT-inducing factors such as N-cadherin and vimentin, and upregulation of the EMT-suppressing factor E-cadherin in the cancer cell lines indicates that the drug induces its anti-migration and invasive activity by modulating the cancer-induced EMT switch in CRC cells. This evidence concerns the gene CDH1 and colorectal carcinoma.