CLCN7 and osteopetrosis: It has been shown that PI(3,5)P2 inhibits ClC-7 activity, but it fails in the case of the Y715C ClC-7 mutation (Leray et al., 2022), which causes lysosomal storage diseases without osteopetrosis (Nicoli et al., 2019; Leray et al., 2022).