Huijuan and others concluded used MAT intervention in STZ-induced DCM and cardiomyocytes isolated from DCM, and found that MAT could suppress PERK expression and reduce cardiomyocyte apoptosis in DCM rats, indicating that MAT could suppress ERS to achieve therapeutic effects in DCM (Hou et al., 2019). This evidence concerns the gene EIF2AK3 and familial dilated cardiomyopathy.