In addition, activation of ERS (increased expression of EIF2α, GRP94, and caspase-3) by Janus kinase and transcriptional activator signaling pathways resulted in disorganized cardiomyocyte arrangement and increased extracellular matrix collagen deposition in diabetic rats, which are involved in the process of myocardial fibrosis (Liu et al., 2018). This evidence concerns the gene HSP90B1 and Myocardial fibrosis.