Ma Weibin et al. used high-fat and high-sugar feeding combined with intraperitoneal injection of STZ (35 mg/kg) to prepare diabetic rats with geranylgeranyl intervention, and the results showed that PUE can lower blood glucose, reduce insulin resistance index, inhibit cardiomyocyte apoptosis, ameliorate myocardial fibrosis, and have a protective effect on the myocardium of DCM rats, as shown by Ma Weibin et al. (Ma et al., 2012a; Ma et al., 2012b; Ma et al., 2013). This evidence concerns the gene INS and Myocardial fibrosis.