CASP12 and familial dilated cardiomyopathy: Zhao Liang-chen et al. (Zhao et al., 2014) applied GFS to treat high-fat-high-glucose (HFHG) combined with STZ-induced DCM rats, and the results showed that GFS improved blood sugar, cardiac enzyme profiles, cardiac myocyte abnormalities, and cardiac myocyte apoptosis in DCM rats, which may be related to the fact that GFS decreased the expression of caspase-12 protein in cardiac myocytes.