CASP3 and type 2 diabetes mellitus: Yu Hai-tao et al. (Yu et al., 2016) used high-fat and high-sugar-fed rats for 1 month, induced T2DM by intraperitoneal injection of STZ, and treated with G-Rg1 at high, medium, and low doses for 3 months to observe its effect on the hearts of T2DM rats; G-Rg1 can reduce cardiac troponin-I., reduce the rate of apoptosis of cardiomyocytes, and reduce fibrosis; and it can reduce GRP78, CHOP, cleaved caspase-12, cleaved caspase-3, and elevated Bcl-cl.