CASP12 and familial dilated cardiomyopathy: In treating DCM, GBE significantly attenuated cardiomyocyte apoptosis, collagen deposition, and inflammatory responses in HFD(basic diet, 78.85%; fat, 21%; and cholesterol,0.15%) combined with STZ(50 mg/kg/day, 5 days)-induced ApoE−/− mice by inhibiting p-JNK, CHOP, and caspase-12 pathways (Tian et al., 2018).