Jia-hui Tian (Tian et al., 2021) et al. demonstrated that increased cardiomyocyte cross-sectional area, HG-induced increase in cardiomyocyte diameter, and markedly elevated levels of the hypertrophic markers cardiac natriuretic peptide and β-myosin heavy chain mRNA were associated with ERS-activated apoptotic pathways induced by ERS activation (GRP78, XBP-1S, ATF6, P-PERK, ATF4, CHOP) in DCM mice. The gene discussed is HSPA5; the disease is familial dilated cardiomyopathy.