Immunohistochemical staining was used to confirm that NEDD4L protein expression was downregulated in LUAD (Li G. et al., 2022), infiltrating ovarian epithelial tumor (Yang et al., 2015), hepatocellular carcinoma (Zhao et al., 2018), renal cell carcinoma (Zhao et al., 2021), rectal carcinoma (Tanksley et al., 2013), gastric cancer (Gao et al., 2012; Jiang et al., 2019), and glioma (He et al., 2012) compared to that in paraneoplastic or normal tissues. Here, NEDD4L is linked to hepatocellular carcinoma.