Moreover, Zhang et al. reported that NEDD4L was phosphorylated by serum glucocorticoid-inducible kinase 1 (SGK1), leading to the release of Smad2 from inhibitory NEDD4L–Smad2 complexes, followed by the upregulation of connective tissue growth factor, ultimately promoting breast cancer metastasis (Liu et al., 2021). The gene discussed is SMAD2; the disease is breast cancer.