Y-box-binding protein 1 (YBX1; also known as YB-1) plays a crucial role in tumor metastasis in colorectal cancer (Evdokimova et al., 2009; El-Naggar et al., 2019; Ruan et al., 2020), and NEDD4L mediates YBX1 ubiquitination and degradation (Chen et al., 2023). The gene discussed is NEDD4L; the disease is neoplasm.