NEDD4L mediates the ubiquitination and degradation of c-Myc, a Myc family member, to inhibit cell viability, cell cycle progression, and glutamine metabolism in esophageal lymphoid carcinoma, as well as cellular glycolysis and chemoresistance in lung cancer (Wang H. et al., 2020; Cheng et al., 2022). The gene discussed is MYC; the disease is lung cancer.