N-Myc downstream-regulated gene-1 (NDRG1), a tumor-suppressor gene, inversely correlates with tumor progression in a variety of tumors, including pancreatic cancer, and NDRG1 enhances the expression of NEDD4L in pancreatic cancer cells, which plays a role in degrading carcinogenic pSMAD2L (Kovacevic et al., 2013). Here, NDRG1 is linked to familial pancreatic carcinoma.