MCL1 and neoplasm: These oncoprotein substrates include cyclin E, c-JUN, c-Myc, NOTCH-1, MCL-1 and KLF5, predominantly comprising transcription factors or key signaling molecules that regulate a wide range of cellular process involved in cell proliferation and tumor progression (Koepp et al., 2001; Strohmaier et al., 2001; O’Neil et al., 2007; Liu et al., 2010; Babaei-Jadidi et al., 2011; Inuzuka et al., 2011; King et al., 2013; Lan and Sun, 2019).