In addition to this, FBXW7 can regulate the tumor immune microenvironment by mediating the degradation of GSK-3β phosphorylated C/EBPδ, influencing macrophage polarization toward M2-type and modulating macrophage innate immune responses (Balamurugan et al., 2013; Zhong et al., 2020). This evidence concerns the gene FBXW7 and neoplasm.