FBXW7 and cancer: Studies have revealed that the presence of cancer stem cells is an important reason why tumors exhibit treatment resistance (Zhou et al., 2017; Li et al., 2021).FBXW7 regulates CSCs self-renewal and cancer progression by reducing core transcription factor activity, activating specific signaling pathways, metabolic reprogramming, and the EMT program (Cremona et al., 2016; Zou et al., 2023).