NFKB1 and neoplasm: For example, anti-inflammatory activity mainly involves NLRP3, NF-κB, mTOR, Notch, and JAK1/STAT3; anti-tumor activity mainly involves PI3K/AKT, NF-κB, TRAF6, and EMT; antibacterial activity mainly involves NF-κB and PPARγ; and their pharmacological effects and mechanisms are shown in Table 2.