NFATC1 and inflammatory bowel disease: In an IBD-induced OP model in rats, emodin (30 mg/kg) could inhibit the formation of osteoclast and reduce the mRNA expressions of tumor necrosis factor receptor-associated factor 6 (TRAF6), nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) and c-fos related to the differentiation of osteoclasts (Luo et al., 2020).