CISH and hepatobiliary disorder: In particular, the significant SOCs that met four criteria were investigations (SOC: 10022891, n = 604), blood and lymphatic system disorders (SOC: 10005329, n = 549), metabolism and nutrition disorders (SOC: 10027433, n = 247), hepatobiliary disorders (SOC: 10019805, n = 89), and congenital, familial and genetic disorders (SOC: 10010331, n = 12).