Previous results by our group also indicated that type 2 diabetic mice exhibited enhanced ERS and increased expression of related factors such as GRP78, PERK and EIF2α, and traditional Chinese medicine and its main components can alleviate ERS by downregulating the expression of related factors (Zhi-hui et al., 2015; Da et al., 2017; Shujing et al., 2017). This evidence concerns the gene EIF2A and type 2 diabetes mellitus.