Our study aims to investigate the specific mechanisms of ShenQiWan in the treatment of DN by observing its effects on renal histopathology in KKAy mice and examining the key factor of endoplasmic reticulum stress, such as Glucose-regulated protein 78 (GRP78), and key factors of mitochondrial fusion, such as Optic atrophy 1 (OPA1), Mitofusin-1 (Mfn1), Mitofusin-2. Here, MFN1 is linked to liver dysplastic nodule.