These results are consistent with those of Hwangbo et al. (2020) and Zhou et al. (2021), and NLRP3-related inflammatory factors, such as caspase-1, pro-IL-18, TNF-α, IL-18, pro-IL-1β, NLRP3, IL-1β, ASC, IL-6, and TGF-β significantly increased (p < 0.001) in NASH rats by HFD-induced. This evidence concerns the gene IL18 and metabolic dysfunction-associated steatohepatitis.