CASP1 and metabolic dysfunction-associated steatohepatitis: In addition, some intestinal florae, such as Lachnospiraceae (family), Blautia (genus), and Christensenellaceae R-7 group (genus), and metabolites, such as CDCA, xanthine, 13(S)-HOTrE, 9-OxoODE, were closely related to the regulation of the NLRP3/ASC/caspase-1 axis by SA, and these findings provide a new research direction for the prevention and treatment of NASH.