However, SA relieved the increase levels of pro-IL-1β, IL-1β, NLRP3, IL-6, TGF-β, TNF-α, pro-IL-18, IL-18, caspase-1, and ASC (p < 0.001) in NASH rats (Figures 4A–J). Here, CASP1 is linked to metabolic dysfunction-associated steatohepatitis.